陈华教授

一、个人简介

陈华,中国科学院上海药物研究所博士(2001-2004)。现为教授，博士研究生导师。主要从事基于糖类衍生物的新药及化学生物学研究。重点开展稠杂氮杂糖、表观遗传糖修饰药物的设计、合成及其抗肿瘤、抗病毒、免疫调节、酶抑制等生物活性研究，发现药物先导阐释作用机制。迄今发表SCI收录论文100余篇；获授权中国发明专利9项，先后主持国家自然科学基金、河北省自然科学基金和河北省教育厅优秀青年基金项目等8项课题。

联系方式：E-mail:hua-todd@163.com

二、主讲课程及研究方向

1.主讲课程：有机化学、波谱分析、有机化学实验

2.研究方向：糖药物化学

三、代表性论文

1.LianhaiYan,Hui Lui, JiajingSun,LigangGao,XinLu,LipingNiu,Xiaoliu Li*,Hua Chen*,Synthesis of tricyclicbenzimidazole-iminosugarsas potential glycosidase inhibitors viaaMitsunobu reaction,Carbohydr. Res.,2019,485,107807(1-8).

2.Zhe Duan,Jingqiu Liu, Liping Niu, Jun Wang,Hua Chen*,Mingqian Feng*,Cheng Luo*,Discovery of DC_H31 aspotential mutant IDH1inhibitor through NADPH-basedhighthroughputscreening,Bioorg. Med. Chem.,2019,27(15),3229-3236.

3.Jiajing Sun,Yaqing Kang, Ligang Gao, Xin Lu, Huanhuan Ju,Xiaoliu Li*,Hua Chen*Synthesis of tricyclic quinazolinone-iminosugarsas potential glycosidase inhibitors viaaMitsunobu reaction,Carbohydr. Res.,2019,478,10-17.

4.Yuxin Feng, Senhao Xiao, Yantao Chen, Hao Jiang, Na Liu, Cheng Luo,ShijieChen*,Hua Chen*,Design,synthesis andbiologicalevaluation ofbenzo[cd]indol-2(1H)-onesderivativesasBRD4inhibitors,Eur. J. Med. Chem.,2018,128,264-273.

5.Li Zhang,YantaoChen,Na Liu,LinjuanLi, SenhaoXiao,Xiaoliu Li,KaixianChen, Cheng Luo,ShijieChen*,Hua Chen*,Design, Synthesis and AntiLeukemiaCells ProliferationActivities ofPyrimidylaminoquinolineDerivatives asDOT1Linhibitors,Bioorg. Chem.,2018,80,649-654.

6.Lianhai Yan, Zhuqing Yin, Liping Niu, Jie Shao,Hua Chen*,Xiaoliu Li*,Synthesis of pentacyclic iminosugars with constrained butterfly-like conformation and their HIV-RT inhibitory activity,Bioorg. Med. Chem. Lett.,2018,28(3), 425-428.

7.Mengying Gao,Yaxi Yang*,Hua Chen*,Bing Zhou*,Rhodium-Catalyzed C-H functionalization of indoles with diazo compounds: synthesis of structurally diverse 2,3-fused indoles,Adv. Synth. Catal.,2018,360(1), 100-105.

8.Penglei Cui,Xiaoliu Li*, Mengyuan Zhu, Binghe Wang, Jing Liu,Hua Chen*, Design, synthesis and antimicrobial activities of thiouracil derivatives containing triazolo-thiadiazole as SecA inhibitors,Eur. J. Med. Chem.,2017,127, 159-165.

9.Yan’en Wang,Ruixue Rong,Hua Chen*,Mengyuan Zhu,Binghe Wang*,Xiaoliu Li*,Triazole-linked fluorescent bisboronic acid capable of selective recognition of the Lewis Y antigen,Bioorg. Med. Chem. Lett.,2017,27(8), 1983-1988.

10.Zhuqing Yin, Mo Zhu, Sinan Wei, Jie Shao, Yuheng Hou,Hua Chen*,Xiaoliu Li*, Synthesis of tetracyclic iminosugars fused benzo[e][1,3]thiazin-4-one and their HIV-RT inhibitory activity,Bioorg. Med. Chem. Lett.,2016,26, 1738-1741.

四、科研项目

1.新型稠杂氮杂糖类糖苷酶抑制剂的设计、合成及活性研究（项目批准号:21772031）,国家自然科学基金项目（2018-2021年,主持人）;

2.新型苯并咪唑并氮杂糖的设计、合成及其糖苷酶抑制活性研究（项目批准号:B2019201398）,河北省自然科学基金项目（2019-2021年,主持人）;

3.新型稠合氮杂糖类HIV逆转录酶抑制剂的研究（项目批准号: B2015201005）,河北省杰出青年科学基金培育项目（2015-2017年,主持人）。