高保祥教师
一、个人简介
高保祥，理学博士，教授，博士研究生导师。1998年7月毕业于北京理工大学高分子材料与工程专业，获工学学士学位。1998年8月-2000年08月在中国乐凯胶片公司感光材料研究所工作。2000年9月-2006年7月在中国科学院长春应用化学研究所高分子物理与化学国家重点实验室师从王利祥研究员，以N-型有机光电功能材料设计与性质研究为主题攻读博士学位，获得理学博士学位。2006年8月到河北大学化学与环境科学学院工作。到河北大学工作以来，以高性能荧光探针设计合成与生物检测成像为研究主题开展科研工作。2011年获得河北省杰出青年基金资助。2012年入选教育部新世纪优秀人才支持计划。2015年10月-2016年9月获得国家留学基金委访问学者项目资助，在德国布伦瑞克工业大学生命科学联合研究中心Philip Tinnefeld教授课题组学习单分子荧光与超分辨成像技术。研究工作得到了国家自然科学基金委、河北省自然科学基金委、教育部、河北省教育厅科研项目的资助。迄今为止，在Advanced Functional Materials、Analytical Chemistry、Organic Letters、Chemical Communications等知名学术期刊发表研究论文30余篇。
联系方式：bxgao@hbu.edu.cn；hbbxgao@126.com
二、主讲课程及研究方向
1.主讲课程：聚合物制备工程，功能高分子材料
2.研究方向：高性能荧光探针设计与合成、荧光生物检测与成像分析
目前研究工作聚焦于高稳定、高亮度、智能型荧光分子探针设计与制备；重要细胞器动态成像与功能分析；生物体系微量元素（铜、锌、铁）荧光检测与功能分析；肿瘤成像与多模式（光-热-化学）治疗。
三、发表论文列表(* = corresponding author)
24. Tingting Sun, Hongmei Liu, Nan Jiang, Qihang Wu, Chaonan Li, Rui Xia, Baoxiang Gao*, and Zhigang Xie*. Unadulterated Organic Nanoparticles with Small Sizes for Robust Tumor Imaging and Photothermal Treatment. Advanced Functional Materials, 2021, 31, 2103714.
23. Shuang Chen, Xu Wang, Yanjun Qiao, Baoxiang Gao*, Min Zheng*, Zhigang Xie*. Controlled synthesis of spindle-shaped terrylenediimide nanoparticles for enhanced tumor accumulation and treatment. Chemical Engineering Journal, 2021, 419, 129552.
22. Yan Zhang, Huanying Zhou, Xu Wang, Xinwei Li, Juandi Wei, Yanjun Qiao, Yifang Song, Baoxiang Gao*. Enhanced brightness and electron affinity of terrylenediimide with sulfone-bridged substituents on the bay region. Chemical Communications, 2021, 57, 651-654.
21. Yifang Song, Xue Zhang, Zixin Shen, Wei Yang, Juandi Wei, Shiyi Li, Xu Wang, Xinwei Li, Qihua He*, Shuchen Zhang, Qisheng Zhang*, and Baoxiang Gao*. Improving Brightness and Stability of Si-Rhodamine for Super-Resolution Imaging of Mitochondria in Living Cells. Analytical Chemistry, 2020, 92, 12137-12144.
20. Suxia Shen, Jingru Yu, Yaomin Lu, Shuchen Zhang, Xuegang Yi and Baoxiang Gao*. Near-infrared probes based on fluorinated Si-rhodamine for live cell images. RSC Advances, 2017, 7, 10922-10927.
19. Shuchen Zhang, Wenfeng Duan, Yanan Xi, Tao Yangab and Baoxiang Gao*. Cell membrane permeable fluorescent perylene bisimide derivatives for cell lysosome imaging. RSC Advances, 2016, 6, 83864-83869.
18. Yanjun Qiao, Jingtian Chen, Xuegang Yi, Wenfeng Duan, Baoxiang Gao*, Yonggang Wu. Highly fluorescent perylene dyes with large stokes shifts: synthesis, photophysical properties, and live cell imaging. Tetrahedron Letters, 2015, 56, 2749–2753.
17. Wenfeng Duan, Huimin Wei, Tengbo Cui and Baoxiang Gao*. A membrane permeable fluorescent Ca2+ probe based on bis-BODIPY with branched PEG. Journal of Materials Chemistry B, 2015, 3, 894-898.
16. Jia Wang, Shilong Zhong, Wenfeng Duan, Baoxiang Gao*. Fluorinated perylene diimides: synthesis, electrochemical-photophysical properties, and cellular imaging. Tetrahedron Letters, 2015, 56, 824-827.
15. Huimin Wei, Nan Jiang, Nan Zhao, Ying Zhang, and Baoxiang Gao*. New Soluble Near-Infrared Dyes Based on Terrylene Diimides with Four Aromatic Heterocycles. Chinese Journal of Chemistry, 2014, 32, 356-360.
14. JinJun Liu, Licui Zhang, Xiaojuan Du, Fengxia Cui, Chunlei Du, Baoxiang Gao*. PEG Encapsulation of Porphyrins for Cell Imaging and Photodynamic Therapy. Letters in Organic Chemistry, 2013, 10, 342-347.
13. Fuli Bo, Baoxiang Gao*, Wenfeng Duan, Hongxia Li, Hongmei Liu and Qianqian Bai. Assembly–disassembly driven off–on fluorescent perylene bisimide probes for detecting and tracking of proteins in living cell. RSC Advances, 2013, 3, 17007-17010.
12. Libin Bai, Wei Li, Jingtian Chen, Fuli Bo, Baoxiang Gao*, Hongmei Liu, Jingjing Li, Yonggang Wu and Xinwu Ba. Water-Soluble Fluorescent Probes Based on Dendronized Polyfluorenes for Cell Imaging. Macromolecular Rapid Communications, 2013, 34, 539-547.
11. Hongmei Liu, Yongli Wang, Chenghui Liu, Hongxia Li, Baoxiang Gao*, Licui Zhang, Fuli Bo, Qianqian Bai and Xinwu Ba. Fluorescent water-soluble probes based on dendritic PEG substituted perylene bisimides: synthesis, photophysical properties, and live cell images. Journal of Materials Chemistry, 2012, 22, 6176-6181.
10. Baoxiang Gao*, Yueling Liu, Huijuan Yin, Yingxin Li, Qianqian Bai, Licui Zhang. Water-soluble Dendritic Polyaspartic Porphyrins: Potential Photosensitizers for Photodynamic Therapy. New Journal of Chemistry, 2012, 36, 28-31.
9. Qianqian Bai, Baoxiang Gao*, Qi Ai, Yonggang Wu, and Xinwu Ba. Core-Extended Terrylene Diimide on the Bay Region: Synthesis and Optical and Electrochemical Properties. Organic Letters, 2011, 13, 6484-6487.
8. Baoxiang Gao*, Defang Xia, Licui Zhang, Qianqian Bai, Libin Bai, Tao Yang and Xinwu Ba. Helical Columnar Liquid Crystals Based on Dendritic Peptides Substituted Perylene Bisimides. Journal of Materials Chemistry, 2011, 21, 15975-15980.
7. Baoxiang Gao*, Hongxia Li, Hongmei Liu, Licui Zhang, Qianqian Bai, Xinwu Ba. Water-soluble and fluorescent dendritic perylene bisimides for live-cell imaging. Chemical Communications, 2011, 47, 3894-3896.
6. Baoxiang Gao*, Hongxia Li, Defang Xia, Sufang Sun, Xinwu Ba. Amphiphilic Dendritic Peptides: Synthesis and Behavior as an Organogelator and Liquid Crystal. Beilstein Journal of Organic Chemistry, 2011, 7, 198-203.
5. Baoxiang Gao*, Licui Zhang, Qianqian Bai, Ying Li, Junwei Yang and Lixiang Wang*. Smectic liquid crystals based on hexaazatriphenylene: potentialOrganic n-Type Semiconductor. New Journal of Chemistry, 2010, 34, 2735-2738.
4. Baoxiang Gao*, Defang Xia, Yanhou Geng, Yanxiang Cheng Lixiang Wang*. Band Gap Tunable for Near-Infrared Absorbing Chromophores with Multi-triphenylamine and Tris (thieno)hexaazatriphenylenes Acceptors. Tetrahedron Letters, 2010, 51, 1919–1921.
3. Baoxiang Gao*, Jingjing Li, Meiye Li, Yanxiang Cheng, Lixiang Wang*. Hierarchical Self-Assembled Nanostructures from the Organic n-Type Semiconductor Hexaazatrinaphthylene . ChemPhysChem, 2009, 10, 3197-3200.
2. Baoxiang Gao*, Yueling Liu, Yanhou Geng, Yanxiang Cheng, Lixiang Wang, Xiabin Jing, Fosong Wang. Starburst substituted hexaazatriphenylene compounds: synthesis, photophysical and electrochemical properties. Tetrahedron Letters, 2009, 50, 1649-1652.
1. Baoxiang Gao, Ming Wang, Yanxiang Cheng, Lixiang Wang*, Xiabin Jing, Fosong Wang. Pyrazine-Containing Acene-Type Molecular Ribbons with up to 16 Rectilinearly Arranged Fused Aromatic Rings. Journal of the American Chemical Society, 2008, 130, 8297-8306
四、科研项目
在研主持项目
1．国家自然科学基金面上项目：两性离子型比率荧光探针设计合成与线粒体嵴超高分辨动态成像分析（项目批准号：22177024，2022年-2025年）
2．河北省自然科学基金：高稳定性近红外荧光分子探针设计合成与生物成像，（项目批准号：B2019201231，2019年-2021年）
结题主持项目
1．国家自然科学基金面上项目：多功能修饰的近红外荧光探针与线粒体内铜离子检测成像，（项目批准号：21274036，2013年-2016年）
2．河北省杰出青年基金：荧光增强型近红外荧光探针的设计合成与蛋白质检测成像，（项目批准号：B2012201031，2012年-2014年）
3．国家自然科学基金青年项目:树状多肽致溶型水溶性荧光化合物的合成与性能，（项目批准号：20804012，2009年-2011年）
4．河北省自然科学基金青年项目:水溶性荧光共轭聚合物的合成与性质，（项目批准号：B2009000169，2009年-2011年）
5．教育部科学技术研究重点项目：新型水溶性荧光卟啉化合物的合成及性质，（项目批准号：210015，2010年-2012年）
