王书香
一、个人简介
王书香,河北大学博士(2003-2005)，教授，硕士研究生导师。迄今为止，发表SCI收录论文60余篇；获授权中国发明专利6项，主持或参与科研课题多项。
联系方式：E-mail: wsx@hbu.edu.cn
二、主讲课程及研究方向
1.主讲课程：有机化学
2.研究方向：有机合成、抗肿瘤药物合成、肿瘤的诊断与治疗、生物小分子探针
三、代表性论文
1.Chunyue Gao, Yi Jin*, Guang Jia, Xiaomin Suo, Huifang Liu, Dandan Liu, Xinjian Yang, Kun Ge, Xing-Jie Liang,Shuxiang Wang*, Jinchao Zhang*. Y2O3nanoparticles caused bone tissue damage by breaking the intracellular phosphate balance in bone marrow stromal cells.ACS Nano,2019,13(1), 313-323.
2. Xiaoran Peng, Jiaxin Gao, Yumeng Yuan, Haitong Liu, Weiyan Lei, Shenghui Li, Jinchao Zhang,Shuxiang Wang, Hypoxia-Activated and Indomethacin-Mediated Theranostic Prodrug Releasing Drug On-Demand for Tumor Imaging and Therapy,Bioconjugate Chem.2019,30, 2828−2843
3. Hongliang Li, Weiyan Lei, Jianong Wu, Shenghui Li, Guoqiang Zhou,* Dandan Liu, Xinjian Yang,Shuxiang Wang,* Zhenhua Li and Jinchao Zhang, An upconverting nanotheranostic agent activated by hypoxia combined with NIR irradiation for selective hypoxia imaging and tumour therapy,J. Mater. Chem. B,2018,6, 2747-2757.
4.Wei Liu, Haitong Liu, Xiaoran Peng, Guoqiang Zhou,* Dandan Liu, Shenghui Li, Jinchao Zhang,* andShuxiang Wang,* Hypoxia-Activated Anticancer Prodrug for Bioimaging, Tracking Drug Release, and Anticancer Application.Bioconjugate Chem.2018,29, 3332−3343.
5. Chao Wang, Dandan Liu, Cuimiao Zhang, Jiadong Sun, Weipei Feng, Xing-Jie Liang,Shuxiang Wang,* Jinchao Zhang*. Defect-Related Luminescent Hydroxyapatite-Enhanced Osteogenic Differentiation of Bone Mesenchymal Stem Cells Via an ATP-Induced cAMP/PKA Pathway.ACS Appl. Mater. Interfaces,2016,8, 11262-11271.
6.Hongliang Li, Wen Peng, Weipei Feng, Yuechai Wang, Guofeng Chen,Shuxiang Wang*, Shenghui Li, Hongyan Li, Kerang Wang, Jinchao Zhang*.A novel dual-emission fluorescent probe for the simultaneous detection of H2S and GSH.Chem. Commun.,2016,52, 4628-4631.
7.Weipei Feng, Chunyue Gao, Wei Liu, Huihui Ren, Chao Wang, Kun Ge, Shenghui Li, Guoqiang Zhou, Hongyan Li,Shuxiang Wang,* Guang Jia, Zhenhua Li, Jinchao Zhang*. A novel anticancer theranostic pro-prodrug based on hypoxia and photo sequential control.Chem. Commun.,2016,52, 9434-9437.
8. Weipei Feng, Yuechai Wang, Shizhu Chen, Chao Wang,Shuxiang Wang*, Shenghui Li, Hongyan Li, Guoqiang Zhou, Jinchao Zhang*.4-Nitroimidazole-3-hydroxyflavone conjugate as a fluorescent probe for hypoxic cells.Dyes and Pigments,2016,131, 145-153.
四、科研项目
1.茚(1,2-b)喹喔啉-5,10-二氧-11-酮肟醚类乏氧激活性抗肿瘤前药的设计、合成与抗肿瘤机制研究（15962602D）河北省应用基础研究计划重点基础研究项目（2015-2017年，主持）
2.乏氧激活性光热剂/热休克蛋白90抑制剂缀合物的合成与抗三阴性乳腺癌研究（B2019201444）河北省自然科学基金（2019-2021，主持）
五、获奖（本人是第一完成人或参与人，河北大学为第一位完成单位获得的政府奖励）
1.超声辐射下邻二醇的合成及机理研究，2007年河北省自然科学奖（三等，第二名）
2.新型贵金属类抗肿瘤配合物的设计、合成及机制研究，2014年河北省自然科学奖（二等，第三名）
