张红蕾
一、个人简介
张红蕾，河北农业大学博士（2011-2015），河北大学博士后（2015-2018）。现为副研究员。迄今为止，发表学术论文26余篇；获授权中国发明专利5项，承担国家自然科学基金1项，省基金1项，主持横向项目2项。获河北省科学技术进步一等奖一项（排名第二），全国互联网+创新创新大赛河北赛区金奖（指导教师）。
联系方式：E-mail：zhl0724@126.com
二、研究方向
微生物源天然产物（可降解高分子材料PHA/抗菌肽等）或植物源天然产物的合成生物学研究及其下游应用探索。
三、代表性论文
1.Honglei Zhang,Chao Zhang, Mengnan Han, Chaohong Pei, Zhidong Xu, and Wei Li*. Efficient biosynthesis of enantiopure tolvaptan by utilizing alcohol dehydrogenase-catalyzed enantioselective reduction.Green Chem.2018,20(6): 1224-1227.
2.Xinyue Li, Jing Chen, Yahui Liu, Shuangqing Fu, Peixun Zhang, Na Zhang, Wei Li,Honglei Zhang*, Traditional Chinese medicine residue enzymatic hydrolysates for production of polyhydroxyalkanoate by newly isolated Bacillus altitudinis,Bioresour Technol.2024, 394: 130277.
3. Mengnan Han, Xiaozheng Li, Xuming Wang, Dexu Liu, Shuangqing Fu, Wenzhi Xu, Wei Li*,Honglei Zhang*. Preparation of polyhydroxyalkanoate-based magnetic microspheres for carbonyl reductase purification and immobilization.Int J Bio Macromol. 2023, 253: 126814.
4. Dexu Liu, Shuangqing Fu, Wenzhi Xu, Xueyu Fan, Shuo Wang, Shengguo Duan, Wei Li,Honglei Zhang.Chitosan-functionalized poly(3-hydroxybutyrate) bead as a novel biosupport for palladium in the Suzuki cross-coupling reaction.Colloids and Surfaces A: 2024, 689:133714.
5. Chao Zhang, Mengnan Han, Fanghua Zhang, Xueli Yang, Jie Du,Honglei Zhang*, Wei Li*,Shengxi Chen. Enhancing Antitumor Efficacy of Nucleoside Analog 5-Fluorodeoxyuridine on HER2-Overexpressing Breast Cancer by Affibody-Engineered DNA Nanoparticle.Int J Nanomedicine. 2020, 15: 885-900.
6.Fanghua Zhang, Chao Zhang, Mengnan Han, Xuming Wang, Shuangqing Fu, Jie Du,Honglei Zhang*andWei Li*. Affibody-Conjugated RALA Polymers Delivering Oligomeric 5-Fluorodeoxyuridine for Targeted Therapy of HER2 Overexpressing Gastric Cancer.Macromol Biosci. 2020, 20(7): e2000083.
7.MengNan Han, XuMing Wang, ChaoHong Pei, Chao Zhang, Zhidong Xu,HongLei Zhang*, and Wei Li*. Green and scalable synthesis of chiral aromatic alcohols through an efficient biocatalytic system.Microb Biotechnol. 2020, doi: 10.1111/1751-7915.13602.
8.Yong Huang, Xuejiao Zhang,Honglei Zhang*, Haixia Qiao, Xiaoyun Zhang, Tianjun Jia, Shuguang Han, Yuan Gao, Hongyuan Xiao, Hejie Yang. Fabrication of silver- and strontium-doped hydroxyapatite/TiO2 nanotube bilayer coatings for enhancing bactericidal effect and osteoinductivity.Ceram Int. 2017, 43(1): 992-1007.
9.Chao Zhang, HongLei Zhang*, MengNan Han, XueLi Yang, ChaoHong Pei, ZhiDong Xu, Jie Du, Wei Li, Shengxi Chen, DNA–Affibody Nanoparticle Delivery System for Cisplatin-Based Breast Cancer Chemotherapy.RSC Advances. 2019,9,1982-1989.
10.HongLei Zhang, Chao Zhang, Chao-Hong Pei, Meng-Nan Han, Zhi-Dong Xu and Wei Li*. Enantioselective synthesis of enantiopure chiral alcohols using carbonyl reductases screened fromYarrowia lipolytica.J Appl Microbiol. 2018,126 (1): 127-137.
11.Honglei Zhang, Chao Zhang, Chaohong Pei, Mengnan Han, Zhidong Xu, Cunhui Li, Wei Li*.Efficient production oftrans-4-Hydroxy-L-proline from glucose by metabolic engineering of recombinantEscherichia Coli.Lett Appl Microbioly. 2018, 66(5): 400-408.
12.Honglei Zhang,Meng Li, Fei Yu, Bo Zhou, Qinghong Hao, Xiuling Wang*. EndophyticBacillus strainsisolated from alfalfa (Medicago sativa L.) seeds: enhancing the lifespan ofCaenorhabditis elegans.Lett Appl Microbiol. 2019, 68(3):226-233.
13. Zhang, Fanghua, Chao Zhang, Shuangqing Fu, Huandi Liu, Mengnan Han, Xueyu Fan,Honglei Zhang*, and Wei Li*. Amphiphilic Cationic Peptide-Coated PHA Nanosphere as an Efficient Vector for Multiple-Drug Delivery.Nanomaterials2022, 12(7), 3024.
四、科研项目
1.可编程聚羟基脂肪酸酯微球基有序自组装多酶分子机器的构建及体外催化机理的研究，国家自然科学基金青年科学基金项目，项目编号：3210120332，2022-2024年，主持人。
2. 姜黄素生物可降解PHA纳米微胶囊的研究，项目编号：横2020050，横向项目，2020-2021年，主持人。
3. 可降解高分子材料PHA的生物合成，项目编号：横2020050，2022-2024年，主持人
4. 新型核苷类靶向抗肿瘤纳米药物治疗乳腺癌的研究，项目编号：521000981310，2019-2022年，主持人
5. 乏氧响应抗菌-抗癌前药的制备及胰腺癌治疗的基础研究，中央引导地方科技发展项目，项目编号216Z2603G，2021-2024年，参与人
