曾乐勇教授 博士生导师

一、个人简介

曾乐勇，男，1981年出生，九三学社社员，理学博士，教授，博士生导师，河北大学坤舆优秀学者，河北省杰出青年科学基金获得者。2005年于河北大学获物理学学士学位，2010年于中科院长春光机所获凝聚态物理博士学位，2010-2012年于中科院宁波材料所从事博士后研究，2012-2016年于中科院宁波材料所工作，历任助理研究员、副研究员，2016年-至今在河北大学化学与环境科学学院工作。主要从事纳米探针制备及其疾病诊疗应用研究，迄今已在Biomaterials等期刊发表学术论文50余篇，申请中国发明专利19项（已获授权13项）。主持国家自然科学基金（4项）、河北省杰出青年科学基金、河北省重点基础研究项目、河北省教育厅青年拔尖人才项目等10余项课题。担任Adv. Funct. Mater., ACS Nano，Small, Nanoscale, ACS Appl. Mater. Interf., J. Mater. Chem.B等10余种国际主流期刊审稿人，是中国化学会、中国生物物理学会、中国材料研究学会和中国生物材料学会会员，是中国医药生物技术协会纳米生物技术分会委员、中国抗癌协会纳米肿瘤学专业委员会委员和中国医师协会介入医师分会介入医学工程与生物技术学组委员。

联系方式：E-mail: zengly@www.makeupbyann.com；zenglyhbu@163.com。17332186862（微信同号）

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二、主讲课程及研究方向

1. 主讲课程：先进材料化学（博士生课程）、无机合成与分析（硕士生课程）、材料结构与表征（硕士生课程）、无机合成与表征实验、综合化学实验

2. 研究方向：生物无机材料与纳米医学、化学生物学

三、代表性论文

2024年

[3]. Gangwan Zhang, Ran Hao, Jiahe Zhang, Di Wu,Leyong Zeng*.Photothermal-promoted O₂/·OH generation of gold nanotetrapod @ platinum nano-islands for enhanced catalytic/photodynamic therapy.J. Colloid Interf. Sci.,2024, 658, 301-312.

[2].Yu Shi,Linna Chang, Chunshu Pan, Hao Zhang, Yiqian Yang, Aiguo Wu*,Leyong Zeng*.Biodegradable hollow mesoporous bimetallic nanoreactors to boost chemodynamic therapy. J. Colloid Interf. Sci.,2024, 656, 93-103.

[1]. Ran Hao, Gangwan Zhang, Jiahe Zhang,Leyong Zeng*.Ultrasmall Au/Pt-loaded biocompatible albumin nanospheres to enhance photodynamic/catalytic therapy via triple amplification of glucose-oxidase/catalase/peroxidase. J. Colloid Interf. Sci.,2024, 654, 212-223.

2023年

[5]. Zhaoyang Wang^#, Zekai Li^#, Yuehua Shi,Leyong Zeng*.Mesoporous polydopamine delivery system for intelligent drug release and photothermal-enhanced chemodynamic therapy using MnO₂as gatekeeper. Regen. Biomater.,2023, 10, rbad087.

[4].Yuehua Shi^#, Tao Liu^#, Zhaoyang Wang, Xiaolong Zhao*,Leyong Zeng*.Cerium dioxide based nanoprobe with self-accelerating cascade catalysis for enhanced catalytic therapy by self-generating H₂O₂and reducing pH value. Chem. Eng. J.,2023, 474, 145513.

[3]. Jiahe Zhang, Linna Chang, Ran Hao, Gangwan Zhang, Tao Liu, Zekai Li, Tianyou Wang,Leyong Zeng*.Copper/gold-modified porphyrinic metal–organic frameworks nanoprobes for enhanced photodynamic/chemodynamic therapy.Chem. Eng. J.,2023, 474, 145485.

[2]. Tianzi Geng^#, Jiahe Zhang^#, Zhaoyang Wang, Yuehua Shi, Yu Shi,Leyong Zeng*.Ultrasmall gold decorated bimetallic metal-organic framework based nanoprobes for enhanced chemodynamic therapy with triple amplification. J. Mater. Chem. B,2023, 11, 2249-2257.

[1].Yuehua Shi, Yu Shi, Zhaoyang Wang, Jiahe Zhang, Ran Hao, Gangwan Zhang, Xiaolong Zhao*,Leyong Zeng*.Glucose-responsive mesoporous prussian blue nanoprobes coated with ultrasmall gold and manganese dioxide for magnetic resonance imaging and enhanced antitumor therapy. Chem. Eng. J.,2023, 453, 139885.

2022年

[3].Zhaoyang Wang, Yuehua Shi, Yu Shi, Jiahe Zhang, Ran Hao, Gangwan Zhang,Leyong Zeng*.Ultrasmall gold coated mesoporous polydopamine nanoprobe to enhance chemodynamic therapy by self-supplying H₂O₂and photothermal stimulation. ACS Appl. Mater. Interfaces,2022, 14, 54478-54487.

[2].Yu Shi,Leyong Zeng*, Yuanbo Pan, Hao Zhang, Zhaoyang Wang, Yuehua Shi, Aiguo Wu*.Endo/exo-genous dual-stimuli responsive gold nanotetrapod-based nanoprobe for magnetic resonance imaging and enhanced multimodal therapeutics by amplifying ·OH generation.Acta Biomater.,2022, 154, 549-558.

[1]. Fan Yang^#, Shaowen Li^#, Meng Jiao, Di Wu, Luna Wang, Zhenyu Cui*,LeyongZeng*.Advances of Light/Ultrasound/Magnetic Responsive Nanoprobes for Visualized Theranostics of Urinary Tumors. ACS Appl. Bio Mater.,2022, 5, 438-450.

2021年

[5]. Tianzi Geng,Lining Zhao, Di Wu*, Hongxin Zhang, Xiaolong Zhao, Meng Jiao,Leyong Zeng*.Bovine Serum Albumin-Encapsulated Ultrasmall Gold Nanoclusters for Photodynamic Therapy of Tumors. ACS Appl. Nano Mater.,2021,4, 13818-13825.

[4]. 孙思佳，吴頔，张贾鹤，范敏菲，曾乐勇*. 超小型锰掺杂金纳米簇及微环境响应的肿瘤可视化诊疗. 中国科学：化学,2021, 51(9), 1259-1268.

[3]. Zhibin Yin^#, Qian Ji^#, Di Wu, Ziwei Li, Minfei Fan, Hongxin Zhang, Xiaolong Zhao,Aiguo Wu*,Liang Cheng*,Leyong Zeng*.H₂O₂-responsive gold nanoclusters @ mesoporous silica @ manganese dioxide nanozyme for “off/on” modulation and enhancement of magnetic resonance imaging and photodynamic therapy. ACS Appl. Mater. Interfaces,2021,13, 14928-14937.

[2]. Sijia Sun, Lining Zhao, Di Wu*, Hongxin Zhang, Haichen Lian, Xiaolong Zhao, Aiguo Wu,Leyong Zeng*.Manganese-doped carbon dots with redshiftedorange emission for enhanced fluorescence and magnetic resonance imaging. ACS Appl. Bio Mater.,2021,4, 1969-1975.

[1]. Yang Gao^#, Zhibin Yin^#, Qian Ji*, Jiabing Jiang, Zhengzheng Tao, Xiaolong Zhao, Sijia Sun, Aiguo Wu*,Leyong Zeng*.Black titanium dioxide@manganese dioxide for glutathione-responsive MR imaging and enhanced photothermal therapy. J. Mater. Chem. B,2021,9, 314-321.

2020年

[6].Ziwei Li, Fan Yang, Di Wu*, Yanhong Liu, Yang Gao, Haichen Lian, Hongxin Zhang, Zhibin Yin, Aiguo Wu*,Leyong Zeng*.Ce6-conjugated and polydopamine-coated gold nanostars with enhanced photoacoustic imaging and photothermal/photodynamic therapy to inhibit lung metastasis of breast cancer. Nanoscale,2020,12, 22173-22184.

[5].Yanhong Liu, Ziwei Li, Zhibin Yin, Hongxin Zhang, Yang Gao, Guoyan Huo*, Aiguo Wu*,Leyong Zeng*.Amplifiedphotoacoustic signal and enhanced photothermal conversion of polydopamine coated gold nanobipyramids for photo-theranostics and synergistic chemotherapy. ACS Appl. Mater. Interfaces,2020,12, 14866-14875.

[4]. Yang Gao, Luyun Zhang, Yanhong Liu, Sijia Sun, Zhibin Yin, Lili Zhang, Aiguo Li, Guangming Lu*, Aiguo Wu*,Leyong Zeng*.Ce6/Mn²⁺-chelated polydopamine@black-TiO₂nanoprobes for enhanced synergistic phototherapy and magnetic resonance imaging in 4T1 breast cancer. Nanoscale,2020, 12, 1801-1810.

[3]. Luyun Zhang^#, Yang Gao^#, Sijia Sun, Zihou Li, Aiguo Wu*,Leyong Zeng*.pH-responsive metal-organic framework encapsulated gold nanoclusters with modulated release to enhance photodynamic therapy/chemotherapy in breast cancer. J. Mater. Chem. B,2020, 8, 1739-1747.

[2]. Yang Gao, Sijia Sun, Zhibin Yin, Yanhong Liu, Aiguo Wu,Leyong Zeng*. TiO₂nanoparticles: Applications in nanobiotechnology and nanomedicine. Chapter 5:Cancer theranostics of white TiO₂nanomaterials. Wiley-VCH,2020, 153-183.（英文专著章节）

[1]. 张艺，邢晶晶，孙思佳，吴頔*,曾乐勇*.绿色方法合成纳米碳点及对Fe³⁺的特异性检测. 发光学报,2020, 41(10), 1249-1254.

2020年之前

[16].Luyun Zhang^#, Chuang Liu^#, Yang Gao, Zihou Li, Jie Xing, Wenzhi Ren, Lili Zhang, Aiguo Li, Guangming Lu*, Aiguo Wu*,Leyong Zeng*.ZD2-engineered gold nanostar@metal-organic framework nanoprobes for T₁-weighted magnetic resonance imaging and photothermal therapy specifically toward triple-negative breast cancer. Adv. Healthcare Mater.,2018, 7, 1801144.

[15].Leyong Zeng, Di Wu, Ruifen Zou, Tianxiang Chen, Jinchao Zhang*, Aiguo Wu*.Paramagnetic and superparamagnetic inorganic nanoparticles for T₁-weighted magnetic resonance imaging. Curr. Med. Chem.,2018, 25, 2970-2986.

[14].Leyong Zeng, Di Wu, Ying Tian, Yuanwei Pan, Aiguo Wu, Jinchao Zhang*, Guangming Lu*.Recent progress in 808 nm excited upconversion nanomaterials as multifunctional nanoprobes for visualized theranostics in cancers.Curr. Med. Chem.,2018, 25, 2954-2969.

[13].吴頔,樊淼,张露云,邢晶晶,吕树芳,曾乐勇*.金纳米星/双锥的可控制备、光热转换及体外光热治疗.发光学报,2018, 39(3), 280-286.

[12].Jie Feng, Limin Chen, Yuanzhi Xia, Jie Xing, Zihou Li, Qiuping Qian, Yan Wang, Aiguo Wu,Leyong Zeng*, Yunlong Zhou*.Bioconjugation of gold nanobipyramids for simultaneous SERS detection and targeted photothermal therapy in breast cancer. ACS Biomater. Sci. Eng.,2017, 3, 608-618.

[11].Leyong Zeng, Zheyu Shen, Aiguo Wu*. Nanomaterials for tumortargeting theranostics.Chapter 3：Magnetic nanomaterials for tumor targeting theranostics. Higher Education Press & World Scientifics,2016, 55-83.（英文专著章节）

[10].Leyong Zeng, Yuanwei Pan, Ruifen Zou, Jinchao Zhang, Ying Tian, Zhaogang Teng, Shouju Wang, Wenzhi Ren, Xueshan Xiao, Jichao Zhang, Lili Zhang, Aiguo Li, Guangming Lu*, Aiguo Wu*.808 nm-excited upconversion nanoprobes with low heating effect for targeted dual-modality imaging and high-efficacy photodynamic therapy in HER2-overexpressed breast cancer. Biomaterials,2016, 103, 116-127.

[9].Yuanwei Pan^#, Ling’e Zhang^#,Leyong Zeng*, Wenzhi Ren, Xueshan Xiao, Jichao Zhang, Lili Zhang, Aiguo Li, Guangming Lu*, Aiguo Wu*.Gd-based upconversion nanocarriers with yolk-shell structure for dual-modal imaging and enhanced chemotherapy to overcome multidrug resistance in breast cancer. Nanoscale,2016, 8, 878-888.

[8].Leyong Zeng, Yuanwei Pan, Ying Tian, Xin Wang, Wenzhi Ren, Shouju Wang, Guangming Lu*, Aiguo Wu*.Doxorubicin-loaded NaYF₄: Yb/Tm-TiO₂inorganic photosensitizers for NIR-triggered photodynamic therapy and enhanced chemotherapy in drug-resistant breast cancers. Biomaterials,2015, 57, 93-106.

[7]. Ling’e Zhang,Leyong Zeng*, Yuanwei Pan, Song Luo, Wenzhi Ren, An Gong, Xuehua Ma, Hongze Liang, Guangming Lu*, Aiguo Wu*.Inorganic photosensitizer coupled Gd-based upconversion luminescent nanocomposites for in vivo magnetic resonance imaging and near-infrared-responsive photodynamic therapy in cancers. Biomaterials,2015, 44, 82-90.

[6].Leyong Zeng, Lijia Luo, Yuanwei Pan, Song Luo, Guangming Lu*, Aiguo Wu*.In vivo targeted magnetic resonance imaging and visualized photodynamic therapy in deep-tissue cancers using folic acid-functionalized superparamagnetic-upconversion nanocomposites. Nanoscale,2015, 7, 8946-8954.

[5].Leyong Zeng, Yuanwei Pan, Shouju Wang, Xin Wang, Xinmei Zhao, Wenzhi Ren, Guangming Lu*, Aiguo Wu*.Raman reporter-coupled Ag_core@Au_shellnanostars for in vivo improved surface enhanced Raman scattering imaging and near-infrared-triggered photothermal therapy in breast cancers. ACS Appl. Mater. Interfaces,2015, 7, 16781-16791.

[4].Leyong Zeng, Wenzhi Ren, Lingchao Xiang, Jianjun Zheng, Bin Chen, Aiguo Wu*.Multifunctional Fe₃O₄-TiO₂nanocomposites for magnetic resonance imaging and potential photodynamic therapy. Nanoscale,2013, 5, 2107-2113.

[3].Leyong Zeng*, Lingchao Xiang, Wenzhi Ren, Jianjun Zheng, Tianhua Li, Bin Chen, Jichao Zhang, Chengwen Mao, Aiguo Li, Aiguo Wu*.Multifunctional photosensitizer-conjugated core-shell Fe₃O₄@NaYF₄:Yb/Er nanocomplexes and their applications in T₂-weighted magnetic resonance/upconversion luminescence imaging and photodynamic therapy of cancer cells. RSC Adv.,2013, 3, 13915-13925.

[2].Leyong Zeng*, Wenzhi Ren, Jianjun Zheng, Aiguo Wu*, Ping Cui.Synthesis of water-soluble FeOOH nanospindles and their performance for magnetic resonance imaging. Appl. Surf. Sci.,2012, 258, 2570-2575.

[1].Leyong Zeng, Wenzhi Ren, Jianjun Zheng*, Ping Cui, Aiguo Wu*.Ultrasmall water-soluble metal-iron oxide nanoparticles as T₁-weighted contrast agents of magnetic resonance imaging. Phys. Chem. Chem. Phys.,2012, 14, 2631-2636.

四、科研项目

1.国家自然科学基金，项目批准号：51772074，2018.01-2021.12，已结题，主持。

2.国家自然科学基金区域创新发展联合基金-重点项目，项目批准号：U20A20254，2021.01-2024.12，在研，参与。

3.国家自然科学基金，项目批准号：U1732127，2018.01-2020.12，已结题，主持。

4.河北省杰出青年科学基金，项目批准号：C2020201025，2020.09-2023.12，在研，主持。

5.中央引导地方科技发展资金项目，项目批准号：226Z1302G，2022.07-2024.12，在研，主持。

6.河北大学多学科交叉研究项目，项目批准号：DXK202002，2021.01-2023.12，在研，主持。

7.国家自然科学基金，项目批准号：U1332117，2014.01-2016.12，已结题，主持。

8.河北省应用基础研究计划重点基础研究项目，项目批准号：17961302D，2017.01-2019.12，已结题，主持。

9.河北省教育厅青年拔尖人才项目，项目批准号：BJ2017002，2017.01-2019.12，已结题，主持。

10.国家自然科学基金，项目批准号：51102251，2012.01-2014.12，已结题，主持。

五、荣誉称号

1.2010年，中科院院长优秀奖。

2.2015年，宁波市领军拔尖人才（第二层次）。

3.2015年，中科院青年创新促进会。

4.2016年，宁波市科学技术一等奖（排名第二）。

5.2017年，河北省教育厅青年拔尖人才。

6.2018年，河北大学坤舆优秀学者。

7.2020年，河北省杰青。