Wang Hongjie's Team Published in Top Journal

Recently, the team led by Professor Wang Hongjie in School of Eco-Environment (Preparatory) obtained original achievements in the field environmental behavior and ecotoxicology of agricultural chemicals. The article was published in Journal of Agriculture and Food Chemistry. (a top journal in this field, IF=5.279) The achievement systematically expounds stereoselective behavior and mechanism of chiral pesticide fosthiazate in vitro metabolism of non-target biological rat and cock.

Ecological safety assessment of chiral pesticides from the level of enantiomers is not only a scientific problem facing the research of pesticide toxicology, but also the practical demand for the development of efficient and eco-friendly pesticides. Fosthiazate is a new type of organophosphorus pesticide, controlling agricultural root knot nematode efficiently, but its residue is harmful to human and ecology. Fosthiazate molecule has two chiral centers, but the toxic effects, metabolic process and toxic mechanism of its four enantiomers on animals are not clear yet. To solve this problem, they defined the stereoselective metabolic behavior of fosthiazate in rat and cock liver microsomes by constructing a metabolic system in vitro. Meanwhile, they preliminarily analyzed the metabolic molecular mechanism through computer-aided simulation technologies including homology modeling, molecular docking and so on. High-resolution mass spectrometry was also used to identify and infer the metabolites and pathways of fosthiazate.

Relevant issues are published by Hebei University as the first unit and communication unit, with Li Lianshan, a member of young faulty in the School of Eco-Environment (Preparatory), as the first author and Professor Wang Hongjie as the corresponding author. The research work has been supported by the National Water Project, the National Natural Science Foundation Project, the "Double First-Class" Discipline Construction Project of Hebei University and the Youth Talent Training Project.

Article Links:https://pubs.acs.org/doi/abs/10.1021/acs.jafc.1c05217